منابع مشابه
Adipose Tissue Glycogen Synthetase
In vitro activation of adipose tissue glycogen synthetase caused a change in kinetic properties of the enzyme. The nonactivated enzyme had a K, for UDP-glucose of 2 m when measured without glucose-6-P. The K, decreased to 0.7 mM in the presence of 2 mM glucose-6-P. The K, for UDP-glucose of the activated enzyme was 0.8 mM. Glucose-6-P affected both the K, for UDP-glucose and the v m&x of the no...
متن کاملHepatic glycogen synthetase deficiency
In the 13 years since hepatic glycogen synthetase deficiency was first described in identical twins no further cases seem to have been observed. We report a child who had suffered from occasional morning convulsions since the age of 7. Three 24-hour metabolic profiles showed fasting hypoglycaemia, hyperketonaemia, but normal lactate. Hyperglycaemia and hyperlactataemia occurred after meals. Glu...
متن کاملHepatic Glycogen Synthetase Deficiency
Dykes, J. R. W., and Spencer-Peet, J. (1972). Archives of Disease in Childhood, 47, 558. Hepatic glycogen synthetase deficiency: further studies on a family. A family with hepatic glycogen synthetase deficiency originally studied in 1962, was restudied 7 years later. Blood glucose concentrations were measured after glucagon administration, and both blood glucose and plasma cortisol were measure...
متن کاملEnhanced glycogen metabolism in adipose tissue decreases triglyceride mobilization.
Adipose tissue is a primary site for lipid storage containing trace amounts of glycogen. However, refeeding after a prolonged partial fast produces a marked transient spike in adipose glycogen, which dissipates in coordination with the initiation of lipid resynthesis. To further study the potential interplay between glycogen and lipid metabolism in adipose tissue, the aP2-PTG transgenic mouse l...
متن کاملRegulation of rat liver glycogen synthetase. Carboxylic acid activation of liver glycogen synthetase.
Rat liver glycogen synthetase is strongly stimulated by cellular carboxylic acids which are intermediates of glycolysis and the tricarboxylic acid cycle. Activation of glycogen synthetase by the carboxylic acids may coordinate hepatic glycogen deposition with the functional status of the tricarboxylic acid cycle. At physiological concentrations of the carboxylic acids, the I form is preferentia...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1973
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(19)43987-2